Univariate and multivariate imaging studies show differential modulation of neural activity in response to identical stimuli, depending on the feature of the stimulus that participants were instructed to attend to (von Kriegstein et al. 2003; Bonte et al. 2014).
Seven multivariate studies have shown a favorable impact of youth access laws on adolescent smoking when controlled for price or other tobacco control policies [ 15- 21].
In addition, multivariate analysis in our initial studies showed that PTEN expression, detected by IHC, was significantly related to OS in gefitinib-treated patients (Buckingham et al, 2007).
Several previous studies showed that multivariate logistic regression is helpful to guard against false positive signals due to confounding by concomitant drugs [ 33, 34].
These results are supported in parts by the reports of other researchers: multivariate studies have already shown that the desire for active participation in treatment decision-making increases in patients with a higher educational level [ 26, 44] and a somewhat lower age [ 44] and tends to decrease the older the patients and the lower their educational level [ 54].
An examination of past KAP studies shows that the most effective methodologies used categorical KAP indices, conduct multivariate regressions to identify, and control for multiple influencing factors.
The remaining four studies showed no significant association, either in the univariate [ 18, 22, 23] or the multivariate analysis [ 21].
In summary, all 5 studies showed that FDG uptake after neoadjuvant therapy was predictive for survival in univariate analysis; however, in multivariate analysis only 1 study showed FDG uptake to be independently predictive for survival.
A few studies showed a significant positive association of hyperglycemia with menopausal status after adjustment for age and other risk factors for diabetes (7, 13, 19), but multivariate analyses in other studies showed no such associations (4, 11, 14, 18, 26).
Even in multivariate studies, depression has been shown to be a strong predictor of postoperative pain [ 15, 29].
