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Weighting the presence of specific susceptible or protective genotypes according to their individual odds ratios (OR from univariate regression or point estimates from multivariate regression) did not significantly improve the discriminatory performance of the raw SNP score (unpublished data).
After reduction of confounding (19), multivariate regression did not change the prediction of fetuin-A.
Multivariate regression did not reveal any association between β-blocker treatment and the primary endpoint (hazard ratio (HR) 0.97; 95%% confidence interval (CI) 0.74 1.27), documented angina (HR 0.85; 95%CI 0.61 1.19) or any of the other composite endpoints and their individual components (Fig. 2).
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Prior to this investigation we defined gender as a possible confounder but multiple multivariate regressions did not confirm this assumption.
But, a multivariate logistic regression did not verify these results.
Multivariate logistic regression did not change these findings.
Additionally, multivariate logistic regression did not identify any associated factors influencing the POS on the left hand.
However age-matched PB across the modalities still showed a significant reduction of pills/day for HHD and in the multivariate regression, age did not come out as a significant factor affecting PB.
A comparison of the results reveals mostly negligible discrepancies, suggesting that a potential violation of the IIA assumption in our (multivariate) main regression does not seem to bias the results and conclusions substantially.
Furthermore, social status as assessed by the occupation of the father did not have an impact on the accuracy of self-reported height, and including social status in the multivariate regression analyses did not change the association between pubertal timing and adult anthropometric and metabolic traits (Supplementary Tables 3 and 5).
The inclusion of the mean RBT allele frequency in the multivariate regression model did not change the outcome: the RBT allele frequency variable was not retained in any of the stepwise models, and the AIC did not differ between the model with and without the RBT allele frequency variable included.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com