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For multivariate models, individuals with prior CVD were defined as those with one or more condition listed under "cardiovascular event history or conditions" or taking CVD drugs in Table 1; hypertensives were excluded from this definition.
In multivariate models, individuals with either prediabetes or diabetes at baseline had significantly lower levels of all sphingomyelins, except C18 0, and dihydrosphingomyelins C16:0 and C18 0 (Tables 3 and 4).
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In a multivariate model, individuals with low SRH were at higher risk of mortality (HR 1.38, 95% CI 1.10 to 1.73) than those with high SRH.
In the second multivariate model, individual characteristics were added, which substantially improved model fit.
In multivariate regression models, individuals identified as black, mixed-race, and Indian were grouped together to form the category of nonwhites.
In multivariate models for individual analytes, the above predictors of creatinine-corrected concentrations generally remained significant, except for age, in years, in relation to methyl paraben in the first sample and > 50 years of age in relation to propyl paraben in the third sample (Table 5).
Nevertheless, a significantly elevated HR was observed in the multivariate model for individuals with triglyceride levels at the fourth and fifth quintiles (i.e., already at triglyceride levels >120 mg/dl [>1.36 mmol/l]) compared with those at the bottom quintile (triglyceride level of ≤66 mg/dl [≤0.75 mmol/l]).
In the multivariate models, compared with individuals with normal glucose values, cost ratios were significantly increased in diagnosed diabetes (2.98 [95% CI 2.50 3.56]) and when antihyperglycemic drugs were excluded (2.30 [1.91–2.30]).
In multivariate logistic regression models, individuals living in households where the head of household was more educated had greater odds of ever having been diagnosed with allergies and/or hay fever.
b Model 1: Multivariate model with individual-level covariates only.
c Model 2: Multivariate model with individual- and area-level covariates.
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