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PR protein expression did not contribute significant prognostic information to multivariate models considering ER and other standard clinico-pathologic features in the GEM or NHS datasets.
PR expression is not associated with prognosis in ER- breast cancer, and PR does not contribute significant independent prognostic information to multivariate models considering ER and other standard clinico-pathologic factors.
Nevertheless, alternative multivariate models considering TFR instead of contraceptive use revealed two opposite effects of TFR on mortality ratios: while displaying an inverse relationship with MMR and MMRAO, TFR showed a direct association with iAMR, explaining 17.2% of the difference in abortion-related mortality among states.
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Multivariate models considered all variables with p<0.1 in the univariate models.
All multivariate models considered age, gender, and all variables that were univariately significant.
The multivariate models considered all variables statistically significant (p<0.05) in the univariate analysis and used forward stepwise methods.
We also fitted a multivariate model considering the indicators simultaneously.
Global model: multivariate model considering status at 6 months based jointly on BADL and IADL assessments.
The most frequent haplotype was taken as the reference and all other haplotypes were included in the multivariate model considering the number of copies of that particular variant.
BADL model: multivariate model considering status at 6 months (deteriorated or not) based on ability to perform basic activities of daily living (BADL) as assessed using the Barthel Index; patients' functional status was considered to have deteriorated if they obtained post-fall scores of <90 points or a pre-post score decrease of more than 10%.
IADL model: multivariate model considering status at 6 months based on ability to perform instrumental activities of daily living (IADL) as assessed using Lawton Scale; patient functional status was considered to have deteriorated if they obtained post fall scores of <5 points or a pre-post score decrease of 2 points.
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