Since the serum creatinine level was included in the definition of severe scrub typhus, six factors except this one were included in the multivariate model for severe scrub typhus.
However, it should be noted that association of HSCs with anemia lost significance in multivariate model and severe confounding by gestational age was observed.
A final analysis showed that when exertion fatigue and general fatigue were entered in the multivariate model simultaneously, both severe exertion fatigue (HR = 2.90, 95% CI: 1.14 7.36, P = 0.03) and severe general fatigue (HR = 3.00, 95% CI: 1.47 6.14, P = 0.003) remained significant predictors of mortality.
The following variables collected at ICU admission were considered for the multivariate model: gender, SAPSII, co-morbidities, severe sepsis, septic shock, invasive mechanical ventilation, glucocorticoid therapy, time to initial antibiotic therapy, hemodialysis-hemofiltration, bacteremia and pathogens with P <0.20 by univariate analysis.
A separate multivariate model for risk factors for severe illness, after age was controlled for, identified serogroup W-135 disease compared with all other cases of known serogroup (OR=2.0, 95% CI 1.2 to 5.2) and being seen by a clinician after <1 day of symptoms (OR=2.4, 95% CI 1.2 to 5.1) as associated with increased risk.
High pre-service alcohol intake was associated with severe AI also after further adjustments in multivariate model (HR = 2.0; 95% CI: 1.2 3.2).
Contrary to the results of univariate analyses, headache time duration ≥ 4 hours and severe headache intensity were not significantly associated with disability in the multivariate model.
If the association of asthma with less severe outcomes was fully explained by associated comorbidities or treatments, then the adjusted odds ratio of asthma with severe outcomes would be expected to approximate one in the final multivariate model.
In multivariate model, participants with diabetes were 2.4 times (OR=2.4, 95% CI=1.1 5.6) more likely to have severe periodontitis.
High BMI and high waist circumference increased the HR for severe AI in the age-adjusted model, but were not significant in multivariate model (Table 2).
