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Finally, the incorporation of a multivariate correction for codon covariation represents an important step forward [27].
Following multivariate correction for GVHD, CMV serostatus and duration of neutropenia the adjusted OR was 3.76 (95% CI 0.90 15.8, p = 0.07).
Thirdly, the incorporation of a multivariate correction for HLA linkage disequilibrium allows the identification of the HLA allele directly responsible for the association, rather than the manual assignment of the responsible allele using p-values post-hoc as employed in previous studies [15].
These results remained similar after multivariate correction for potential confounders (Supplemental Table 4).
We calculated adjusted hazard ratios after multivariate correction for age and smoking.
$Multivariate correction for sex, age and underlying disease (forward stepwise adjustment) using logistic regression analysis.
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Vandergrift et al. [ 27] found a significantly shorter TTC following mastectomy only, even after multivariate correction.
Multivariate analyses and correction for multiple comparisons confirmed its prognostic significance for OS.
In general, few studies identified risk factors using multivariate analysis or correction for confounding factors [ 4, 15, 19].
Multivariate analyses and correction for multiple testing were not performed in view of the exploratory nature of this study.
We wanted to check if the significant differences were the same as for our multivariate models without correction for temporal dependency.
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