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Interestingly, in this study, p.Leu1007fsX1008 was the most strongly CD-associated gene variant in a combined multivariate analysis (Supplementary Data, Table S6).
This was not significant in multivariate analysis (Supplementary Table 3).
These findings were confirmed on multivariate analysis (Supplementary Table S2).
Duration and ZnT8A emerged as the only factors significantly related to C-peptide levels in multivariate analysis (Supplementary Table 2).
Other SNPs were not associated with POP neither in the crude nor in the multivariate analysis (Supplementary Table 3).
Expression of LOX correlated with patient survival (Fig 1C), and we confirmed this correlation using multivariate analysis (Supplementary Table S2).
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An LND⩽0.07 was associated with better local control, locoregional control and DFS in a multivariate analysis (P<0.01, Supplementary Table 3).
To identify prognostic factors for long-term survival of ≥2 years, candidate factors were assessed by multivariate analysis (see supplementary material, available at Annals of Oncology online).
Remarkably, in the multivariate analysis model (Supplementary Table 3), DNA-PKcs activity was significantly associated with overall survival, together with patients' sex, serum AFP level and HCC apoptosis and microvessel density.
Finally, we analysed the prognostic value of HPV16 alone as well as in correlation with CD163 that showed significance in multivariate analysis and CD11b (Supplementary Tables 4 and 5; Supplementary Figure 4A and B).
Demographics and clinical factors influencing survival were assessed with univariate and multivariate Cox model analysis (Supplementary material and Supplementary Table 7).
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