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To elucidate the effect of age vs treatment variables on survival, we performed a multivariate analysis stratified on tumour characteristics, correcting for year, stage at diagnosis and oncological treatment (Table 4).
Overall, using multivariate analysis stratified by site and controlling for age, patients receiving DP had a lower risk of PCR confirmed treatment recrudescence than with the comparator treatments (AHR = 0.32, 95%CI 0.21 0.48, P = 0.001).
In the DP groups, using multivariate analysis stratified by site at Day 28, age (as continuous variable) was the only predictor of recurrence and recrudescence in Africa or Asia when analyzed separately.
Overall, in the multivariate analysis stratified by site, DP had a greater post treatment prophylactic effect (against new infections) at Day 28 against P. falciparum compared to the other treatments (AHR = 0.47, 95%CI 0.33 0.67, P = 0.001).
In multivariate analysis stratified tumor size and LN status were included as covariates.
If interaction could be confirmed, we then repeated the multivariate analysis stratified according to the HbA1c subgroups.
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Our analysis used multivariate Cox analysis stratified for propensity scores and exposure to glucose-lowering drugs.
On multivariate survival analysis, stratified by tumour site, increasing age and mGPS were associated with increased overall and cancer-specific mortality (all P<0.001).
Multivariate regression analysis stratified by weight related health risk was not applied, considering the small sample size of persons intending to use weight-related care from a care provider.
Cox proportional hazards model multivariate regression analysis (stratified by tumour site) was used to determine the relationship between patient characteristics, the mGPS and each biochemical parameter and survival (Tables 1C, D, 2C and D).
*β-coefficient; Protein creatinine ratio (PCR) Results of multivariate linear regression analysis, stratified for gender are outlined in Table 3.
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