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With selected cases and controls matched to exclude exogenous source of IR-MDRAB, multivariate analysis still identified carbapenem as the only independent risk factor (adjusted OR, 1.48; 95% CI, 1.14 to 1.92).
However, due to a presumed overlap between LBW and prematurity [ 4] we believe that the multivariate analysis still provides important information.
Adjusting for age, adjuvant chemotherapy, adjuvant endocrine therapy, and type of BRCA mutation in a multivariate analysis still showed no association of radiotherapy on CBC risk (HR 0.74, 95%% CI 0.40 1.37 and HR 0.96, 95%% CI 0.23 3.97, respectively).
While other patients' characteristics such as age, sex, smoking status, tumor size, tumor cell content, pTNM stage, or differentiation grade, had no impact on the engraftment rates in a multivariate analysis, still the univariate analysis showed that the male sex, higher pTNM stage, and a moderate to poor differentiation grade affected the take rate of PDXs.
Similar(56)
These associations were attenuated slightly in multivariate analysis but still remained statistically significant.
Nevertheless, in multivariate analysis, abn(17p) still remained a significant impact factor for better OS, whereas age did not.
In the multivariate analysis, we could still demonstrate association between HHV-8 status and MSM exposure, hepatitis B and black ethnicity (Table 2).
In the multivariate analysis, there was still an inversed association between parity and risk (P=0.02).
In the multivariate analysis, TD was still correlated with response (p = 0.019).
Although relying on multivariate analysis, there is still room for non-casual associations; hence, these should be validated in other studies.
Of note, when compensating for stage of tumour on multivariate analysis, there is still a large influence from the diagnostic category, suggesting histological heterogeneity.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com