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In multivariate analysis, serum sodium was validated as an independent prognostic factor (P=0.001).
However, on multivariate analysis, serum Cr level lost its significance (β=−0.015, P=0.899).
In multivariate analysis serum hCGβ, tumour stage and grade were independent prognostic variables.
In the multivariate analysis serum glucose was no longer predictive of outcome.
In the multivariate analysis, serum uric acid was analyzed for association with potential covariates age, sex, BMI, T2D, HTN, and eGFR.
After multivariate analysis, serum creatinine, fasting glucose, total cholesterol, TNF-alpha, andumin, APACHEACHE II score were still independently associated with A-FABP.
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In multivariate analysis, the serum PIVKA-II level (P < 0.001) and AFP level (P = 0.049) in stage A and serum PIVKA-II (P = 0.033) in stage C were independent predictive factors of extrahepatic metastases.
In multivariate analysis, only serum GGT above the median level, severe fibrosis, and genotype 1 infection were negatively and independently associated with SVR.
On multivariate analysis, pretreatment serum EPCA level held the most significantly predictive value for the biochemical recurrence and androgen-independent progression among pretreatment variables (HR = 4.860, P<0.001 and HR = 5.418, P<0.001, respectively).
Interestingly, in the multivariate analysis, high serum PTH and FGF23 levels associated with aortic valve calcification.
Both univariate and multivariate analysis selected serum NSE and not HSI as the most influential prognostic factor in SCLC.
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