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The two SNPs remained associated in a multivariate analysis (see Table 7).
In addition, by clinical experience and literature review, we decided to include age as a covariate in the multivariate analysis, see Table 3.
Among all UGT1A variants studied, UGT1A1*28 was the most widely correlated with severe toxicity in the multivariate analysis (see Table 4).
To identify prognostic factors for long-term survival of ≥2 years, candidate factors were assessed by multivariate analysis (see supplementary material, available at Annals of Oncology online).
The detailed questionnaire design allowed for estimation accuracy to be explored with respect to sociodemographic and alcohol consumption variables in the multivariate analysis (see Materials and Methods).
One possibility to overcome this issue is to limit the number of groups to test, thanks to the use of multivariate analysis (see [ 8]) or clustering techniques for instance.
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Patient data collected at the time of ED triage and used as candidate predictor variables for under- and over-triage by multivariate logistic regression analysis (see below) included age, sex, vital signs, patient-reported pain score, chief complaint category, and arrival time.
Both ANLN and PBK were significant independent predictors of BCSS when adjusted for other well-established variables, using multivariate Cox regression analysis (see Additional file 1: Table S4).
Due to the risk of false positives brought by our computation of 22 correlations, we performed a multivariate ordinal regression analysis; see Table 3.
Multivariate logistic regression analysis (see Methods) revealed that treatment with DPP4i (OR = 0.21, 0.05 0.87) were independently associated with a lower risk for in-hospital complications.
For the current setting, we assigned τ1 equals 1 and τ2 equals −1.0011, and these were chosen from our experimental analysis (i.e., by performing multivariate logistic regression analysis (see Section 3.3 for details)).
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