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Although this study is one of the largest focusing on this topic, the number of patients included in the multivariate analysis remains limited, emphasising the need for larger, prospective multicentre studies in the future.
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Employment is not a significant predictor on multivariate analysis, but remains a significant association in the cluster of low decision-making scorers.
Despite the lack of significance in multivariate analysis, HPR remains an important piece of information after preoperative chemotherapy, because it represents an in vivo testing of the chemosensitivity of the tumour and may serve as a stratification criterion for tailored postoperative treatment in future studies.
While it was lost after multivariate analysis, this trend remains intriguing because multiple partnership, sildenafil use, and lower rates of condom use have all been previously reported in elderly individuals [29], [30].
On the basis of multivariate analysis, GRIA2 expression remains a significant predictor of better progression-free survival (P=0.026; Table 5).
The difference remains significant in multivariate analysis after adjusting for age (<60 or ≥60), stage (LD or ED) and tumor burden (HR = 8.4, p = 0.008 for PFS and HR = 4.7, p = 0.021 for OS; Supplementary Data 5).
In multivariate analysis only exposure to colonized pigs remains as a significant risk factor (Table 4).
Only the rs2530797A/G polymorphism remains associated into multivariate analysis.
The association between vertebral fracture and λ light chain remains significant in multivariate analysis after adjustment on BMD, age, sex and BMI.
A multivariate analysis indicates that percentage body fat remains a significant predictor of impaired performance, when accounting for diet and knee osteoarthritis score (Table 3).
On multivariate analysis, it appears that 9p deletion remains a poor prognosticator for both outcomes, confirming the findings from previous studies based on I-FISH.
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