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In the multivariate analysis, high TGF-β1 expression was an independent negative prognostic factor for DSS (HR = 1.6, 95% CI = 1.1 2.4, P = 0.019) in addition to tumor depth, malignancy grade, metastasis at diagnosis, surgery and positive resection margins.
In the multivariate analysis, high expression of VEGFR-3 (P = 0.042, HR = 1.907, 95% CI 1.024-3.549) wan an independent significant negative prognostic marker for DSS among patients with wide resection margins.
In multivariate analysis, high risk was the main predictor of recurrence.
In multivariate analysis, high MAP-tau expression was again associated with significantly improved OS.
Interestingly, in the multivariate analysis, high serum PTH and FGF23 levels associated with aortic valve calcification.
At multivariate analysis high p27kip1 expression demonstrated to be significant (p = 0,01).
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In multivariate analysis, higher APACHE score, thrombocytopenia, and higher serum SUPAR levels were statistically significantly associated with a higher risk of ICU mortality.
Using multivariate analysis, higher thresholds of Hb was not associated with ICU mortality (odds ratios: OR [confidence interval: CI] 1.19 [0.76-1.87] and 2.37 [0.75-7.53] for Hb≤11g/dL and Hb>11g/dL groups, respectively, compared with Hb≤9g/dL) or in-hospital mortality (OR 1.11 [0.75-1.66] and 0.94 [0.35-2.56], respectively).
In the multivariate analysis, high-level TUBB3 expression was an independent prognostic factor for poor PFS (HR 2.74, 95% CI 1.91-3.91, P = 0.001).
On multivariate analysis, high-level CCR7 staining predicted relapse-free (hazard ratio 3.0, 95% confidence intervals 1.1 8.0, P=0.026) and disease-specific (hazard ratio 10.2, 95% confidence intervals 2.1 48.6, P=0.004) survival.
In the post hoc multivariate analysis, higher linear BCI was associated with shorter RFS (p = 0.002).
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