In the multivariate analysis with established prognostic parameters (stage, grade) we found an independent prognostic value for cathepsin D (P-value = 0.002, relative risk = 3.8, 95% confidence interval 1.4 - 10.0).
Multivariate analysis further established that, adjusting for other parameters, Vt, PmEI and PmEE did practically not depend on altitude.
In multivariate analysis, the established prognostic factors (Gleason score, PSA at diagnosis, presence of bone metastasis) were unable to predict the likelihood of further hormone response following failure of chemotherapy.
In a more recent study, Liegig et al. suggested that PNI is correlated with decreased survival on a multivariate analysis and established that PNI is an independent predictor of outcomes in colorectal cancer patients [ 20].
A prognostic signature partly characterized by hypoxia-related genes was identified among 89 genetically complex pleomorphic primary STS and could, in a multivariate analysis including established prognostic markers, independently predict the risk of metastasis with a hazard ratio of 2.2 (P = 0.04).
The pH, catalyst amount and hydrogen peroxide were simultaneously varied using multivariate analysis to establish the weight of each variable in the COD and AOX removal after 180 min of reaction.
Therefore, a multivariate analysis that establishes sharp boundaries among classes is sought and, accordingly, one nearest neighbor is employed.
In this study, univariate and multivariate analysis to establish relationship between diabetes and associated risk factors was not conducted because the number of observed cases was small.
Reduced C4 levels, positive RF and the presence of serum M component (present in type I or II cryoglobulins, or detected by serum protein electrophoresis and immunofixation) were the laboratory items selected by the multivariate analysis, to establish a CV in patients with positive serum cryoglobulins.
We performed multivariate analysis and formally established that the 19-gene model maintained independent prognostic significance adjusted for confounding factors, in both training and the two independent validation sets (Figure 4A and Table 3).
