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After multivariate analysis, elevated and highly elevated serum GGT levels were independently associated with poorer survival.
In multivariate analysis, elevated RDW at diagnosis was a poor prognostic factor for PFS (HR 3.21, 95% CI 1.24 8.32) after adjustment with other myeloma-related prognostic factors.
In multivariate analysis elevated levels of this marker were also found to be associated with poor overall and disease-free survival (P = 0.01 and P = 0.003 respectively).
On univariate and multivariate analysis, elevated monocyte counts (≥545/mm), tumor size ≥5 cm, non-capsulation, and multiple tumors were associated with poor disease-free survival (DFS) and overall survival (OS).
In both Cox univariate and multivariate analysis elevated levels of (total) tPA determined in the pellet extracts, but not in cytosols, were associated with prolonged relapse-free (RFS) and overall survival (OS).
High ALK mRNA levels were of prognostic relevance by Cox univariate regression analysis and correlated with increased risk of relapse (P=0.001) and survival (P=0.01), whereas by multivariate analysis elevated ALK mRNA expression resulted a negative prognostic marker when clinical stage was not included.
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Multivariate analysis showed that elevated IL-8 expression remained an unfavourable prognostic factor for both DFS and OS even after adjustment for pathological stage (Table 1).
On multivariate analysis, peritoneal soiling (P<0.01), elevated preoperative white cell count (P<0.05) and mGPS (P<0.01) were independently associated with increased risk of developing a postoperative infection.
On multivariate analysis, poor performance status, elevated initial WBC and alkaline phosphatase and low serum albumin were associated with reduced survival (P < 0.05), and initial raised WBC showed an association with reduced likelihood of response (P = 0.002).
In multivariate analysis, the class of drug, elevated platelet count, low white blood count and gender were the only significant independent variables for toxicity (Table 6 >).
Multivariate analysis did not identify slightly elevated AFP levels (6-20 ng/mL) as an independent risk factor, but did identify both stratified WFA+-M2BP levels (1-4 and ≥4) as independent risk factors.
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