The independent role of high TOPO-II α expression as marker of poor prognosis is sustained by the lack of association with any of the clinico-pathological parameters examined, and also by the results of multivariate analysis documenting the persistence of the unfavourable significance of high TOPO-II α expression after adjusting for stage of disease, residual tumour, and platinum responsiveness.
Multivariate analysis documents that mothers having lower levels of education, economic status and empowerment, belonging to rural area, residing in provinces other than Punjab, working in agriculture sector and mothers who are young are more likely to give births at home.
Due to this low number, an ISTH score of >3 was entered in the multivariate analysis to document the possible role of coagulation disorders.
Multivariate analysis with logistic regression documented that blood type O was an independent factor for ulcer development in low-dose aspirin users with an odds ratio of 2.1 (95% CI: 1.1 4.2).
However, a recent German, multicenter, retrospective review documented, in a multivariate analysis, five negative prognostic factors, including performance status, platinum-sentive disease, tumor grading, FIGO staging, and presence of multiple vs single lesions.
In multivariate analysis, predictors of complications were severe tonsillar inflammation (documented among 13.0% (1652/12 717); odds ratio 1.92, 95% confidence interval 1.28 to 2.89) and severe earache (documented among 5.0% (667/13 3.02, 3.02, 1.91 to 4.76) (table 2).
The low numbers of documented Wells scores made the multivariate analysis of independent predictors of diagnostic yield of CTPA that included this parameter difficult to interpret.
The strong inverse association of childhood AML with weight that was found in the multivariate analysis of our study has not been previously documented in childhood.
In this study, such a prognostic significance of ER expression could not have been documented using either univariate analysis or multivariate analysis.
The univariate analysis sought factors that were significantly associated with the number of items documented per record, and was followed by a multivariate analysis to derive estimates of strength of association adjusted for confounding.
