Most importantly, in our study nuclear PTMA expression emerged as an independent poor prognosticator in multivariate analysis, in comparison with the known clinical and pathological factors for HNSCC including histological grade [well differentiated (WD), moderately differentiated (MD) and poorly differentiated (PD ], T-stage, lymph node positivity and tumor stage.
Follow-up examination was performed by the operating surgeon (O.S .. Statistics included both univariate and multivariate analysis for comparison of success rates using the SPSS® software package.
Chemotherapy with docetaxel was significantly associated with mild swelling on multivariate analysis in comparison to both no chemotherapy and non-taxane chemotherapy groups (HR 1.63, p = 0.0098; HR 2.15, p = 0.02, respectively).
However notable differences in the reduced ENMs, multivariate analysis, and direct comparisons of climatic variables also suggest a potential for niche evolution within the areas inhabited by the different genetically distinct populations, where natural selection causes niche parameters to diverge in association with lineages [51].
In the multivariate analysis, stepwise model comparison was used to determine the best model.
Multivariate analysis of this comparison revealed clusters (OR: 9.7; 95% CI: 1.1 85; P = 0.039) and chills (OR 12; 95% CI: 1.8 83; P = 0.010) as the 2 independently significant features for influenza A infection.
Taking into account the multivariate analysis and model comparison approach, therefore, and considering the clinical outcome, we could speculate that the role of the EBV is more pronounced in tumor tissue than in peripheral blood.
In the principal (prevalence) and bivariate association analyses we set statistical significance at P < 0.05; in the multivariate analysis, because of multiple comparisons we set it at P < 0.02.
All parameters are undergoing multivariate analysis and further statistical comparison with respect to time to relapse of disease.
For the outcome of case fatality by 30 days, Kaplan Meier estimates and the log-rank test were used for univariate analysis and Cox proportional hazard models for multivariate analysis, with the multivariate comparison predefined as the primary outcome measure.
