The key finding of our study is that in uni- and multivariate analyses high serum levels of miR-202 proved to be an independent prognostic factor.
Multivariate analyses, including serum markers, CTC and known clinical prognostic factors, have been reported previously: CTC and CEA were the two blood markers independently associated with PFS, whereas CTC count was the only blood marker independently associated with OS [ 9].
In addition, we did not control for history of Helicobacter pylori (H. pylori) infection in multivariate analyses, because serum IgG antibodies to H. pylori whole-cell antigens (Helico-G) and CagA were not measured for majority of study participants [ 16].
In both univariate and multivariate analyses, the serum concentration of TNFR2 is strongly associated with the rate of eGFR loss, secondarily with the imputed baseline eGFR (a consequence of what damage has already accumulated) and ultimately the imputed time to ESRD.
In supplementary multivariate regression analyses, serum uric acid levels were replaced by hyperuricemia included as a categorical measure.
In multivariate regression analyses, serum 25(OH D was a significant independent predictor of insulin sensitivity (ISOGTT and HOMA-IR) and β-cell function (IGI/IR and ISSI-2) across all models (Table 1).
Multivariate analyses revealed that serum cystatin C, eGFR, serum creatinine and LVMI were independently correlated with AASI.
In multivariate analyses, cancer and serum albumin were positively correlated, and IDWL and hemoglobin were negatively correlated with sNa (Table 2).
Multivariate analyses defined high serum levels of DKK-1 as an independent prognostic marker in prostate cancer (HR 3.73; 95%CI 1.44-9.66, p = 0.007).
In multivariate analyses with either serum ionized Ca, parathyroid hormone, or inactive or active vitamin D3 as the dependent variable, we found no significant associations with kidney Cd (dichotomized or continuous).
