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For further univariate and multivariate analyses, samples were dichotomised according to the median BSI value slightly modified as described previously (Nehls et al, 2005) as follows: low BAX expression, BSI <12, and high BAX expression, BSI⩾12.
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Finally, in the multivariate analyses, the sample was further restricted to allow for a longer time period (3-year lag), with the final sample of 44,634 (56%%).
Multivariate analyses revealed sample clustering by season, with a relevant proportion of the variance explained by day length, temperature, salinity, phototrophic nanoflagellate abundance, chlorophyll a, and silicate concentration.
Since patients with missing data were excluded from multivariate analyses, the sample size was reduced among the oncology patients.
For the purpose of the study's emphasis on childbearing, women were oversampled; multivariate analyses use sampling weights to reflect the gender composition of the area's overall population.
Ki-67 is an independent prognostic factor for disease-free survival (HR 1.05 1.72) in multivariate analyses studies using samples from randomized clinical trials with secondary central analysis of the biomarker.
For the analysis of associations with diagnosis of major depressive episode in both univariate and multivariate analyses, inverse probability sampling weights were used to account for the different sampling percentages of high, medium and low SRQ/EPDS scorers.
Bivariate and multivariate analyses adjusted for sampling weights and clustering effects at the health center level.
To maintain adequate power in multivariate analyses, an approximate sample size of 5 20 cases is required per adjustment variable.
We have used hypothesis-based cDNA arrays and quantitative PCR to quantify the expression of selected sets of genes followed by multivariate analyses in multiple independent samples.
Finally, all matrices have limitations inherent in their development that relate to multivariate analyses performed in limited samples of patients.
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