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Statistical significance was reported at the 95% confidence level (P < 0.05), and the multivariate analyses repeated-testing error was controlled for using a 5% false discovery rate correction [ 35].
Importantly, we describe the variability of the weights assigned to individual transcripts in multivariate analyses in repeated studies and suggest that the variability we describe may be the cause of inability to repeat many earlier studies.
Crossover and multivariate analyses for repeated measures showed no apparent difference in the response to mexiletine versus placebo.
Multivariate analyses were repeated to include patients with missing values.
The multivariate analyses were repeated after 1 year.
To compare the two chemotherapy groups, the multivariate analyses were repeated using Cis<850 mg as reference.
Multivariate analyses were repeated to include patients with missing values, indicating similar results as above.
Multivariate analyses were repeated for each cohort excluding patients with M1 disease (6.1%, n = 92).
Multivariate analyses were repeated to include patients with missing values with similar results as described above.
Multivariate analyses were repeated after replacing continuous variables with median SUVmax, median tumor size, and median age.
Regarding CAC the multivariate analyses were repeated after log transformation of CAC levels in those patients with CAC baseline levels greater than zero (n = 61).
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