Exposure measures included spot urine samples for both studies; however, Tellez-Plaza et al. (2008) used multivariate adjustment for creatinine to adjust for urine dilution effects, whereas Whittemore et al. (1991) directly adjusted UCd measurements for specific gravity.
However, after multivariate adjustment, this association was no longer significant, with a multivariate adjusted HR of 1.11 (95% CI 0.87 1.41).
These estimates also shifted towards the null after multivariate adjustment.
After multivariate adjustment, the linear relationship was still present.
Multivariate adjustment for confounders was performed with a Cox proportional hazards model.
However, rs2468844 was associated with cIMT only in a recessive model after multivariate adjustment (P = 0.011).
These associations disappeared after multivariate adjustment, especially age adjustment.
All associations remained after multivariate adjustment.
In addition to the multivariate adjustment, we applied the standard multivariate method for energy adjustment.
However, this was not significant after multivariate adjustment (P = 0.174).
