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Common areas of weakness were failure to perform subgroup analysis for AC and SCC; failure of quality control such as reporting call rates and Hardy Weinberg equilibrium; failure to perform/report multivariate adjustment of HRs; and failure to adjust for multiple comparisons.
After multivariate adjustment of a Cox proportional hazards model for several established risk factors for cardiovascular disease, the number of risk alleles were significantly and independently associated with cardiovascular events (p value<0.05).
Multivariate adjustment of outcomes was done using propensity score matching.
However, after multivariate adjustment of confounders, A1C level remained as an independent predictor of incident diabetes.
Multivariate adjustment of effect sizes was carried out by 57 studies (31.3%).
After multivariate adjustment of conventional risk factors (hypertension, dyslipidemia, smoking, obesity, and family history of CVD), the overall risk of CVD was greatly attenuated in all categories.
Similar(53)
We performed multivariate adjustments of the associations by analysis of covariance and estimated adjusted means.
In the repeated mixed model analysis, several markers of disease activity were associated with NT-proBNP levels, but after multivariate adjustment for time of follow-up, only CRP remained a significant predictor in the final model (Table 4).
After multivariate adjustment for all of these factors, there was a trend across the three FLI categories.
Limitations of this study include back-extrapolation of serum TCDD level for many participants, and the lack of multivariate adjustment for potential confounders.
Multivariate adjustment for the probability of survival (Ps) by TRISS method confirmed CT as an independent predictor for 28-day mortality (adjusted OR, 7.22; 95% CI, 1.76 to 29.60; P = 0.006).
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