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27 We found that the ORs of upper quartiles with the lowest quartile as a reference attenuated after multivariate adjustment in both men and women, indicating that these adjusted factors could affect the association of corin and hyperglycaemia.
The multivariate adjustment in both analyses included year, month of the year, and months with activated rule.
A significant association between serum urate and IMT persisted after multivariate adjustment in a group of 120 obese children [ 27].
Multivariate adjustment in a stepwise regression model including esRAGE, age, gender, body-mass-index, albumin excretion rate and HbA1c showed an independent association for esRAGE with sRAGE only.
Our study design is more effective in reducing confounding than a simple multivariate adjustment in the total cohort, the most widely used method in this field of research.
In that study, each standard deviation above baseline NT-proBNP predicted a 48%% increased risk of dementia during 14-year follow-up after multivariate adjustment in men, but no such association was found in women.
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In our prospective study, with 4067 incident endometrial cancers and a wide range of tea consumption, we showed no association between tea consumption and endometrial cancer risk either before or after multivariate adjustment or in subgroups by BMI or smoking.
After multivariate adjustment, those in the lowest eGFR/highest ACR category (eGFRcys< 30 ml/min/1.73 m and ACR ≥ 1000) had more than a 4-fold increase in hs-TnT compared to the referent group (eGFRcys> 60 ml/min/1.73 m and ACR< 30).
However, after multivariate adjustment the benefits in survival (hazard ratio: 0.828; 95% confidence interval: 0.646 1.061; P = 0.136; Figure 3) did not persist.
Multivariate adjustment for differences in sociodemographics, health risk factors, physical health, and health beliefs and attitudes had little effect on the relationships.
Univariate associations between patient characteristics and healthcare costs and multivariate adjustment are summarized in Additional file 3 and Additional file 4. Differences between PCPs were negligible.
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