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Additional multivariable models restricted to HIV-infected individuals compared thresholds of viral load and CD4 levels.
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We performed both univariable and multivariable analyses (i.e., models restricted to respiratory viruses at single lags, as well as models that included respiratory virus effects at multiple lags and environmental covariates).
26 27 28 In sensitivity analyses, we examined associations between overall mortality and baseline characteristics by using multivariable Cox proportional hazards regression models restricted to patients with radiographic osteoarthritis defined by a more stringent Kellgren-Lawrence grade of at least 2 and restricted to patients with complete information on covariates.
When the multivariable model was restricted to children < 5 years of age on 9/11, the associations were similar to those for the group overall.
For multivariable modelling, analysis was restricted to those observations with complete data on all variables included in the multivariable model.
In these multivariable models, continuous variables were modelled using restricted cubic smoothing splines with five knots to relax the assumption that continuous variables were linearly related to the mortality [ 33].
Even for the three most commonly occurring NADC, our multivariable models to identify predictors of survival were restricted by low power.
However, in a multivariable model for cough duration restricted to patients in the former group, HIV-infection [estimate = −14.85 (−27.87, −1.838); p = 0.0267], and heavy alcohol usage [estimate = 85.14 (44.77, 125.5); p <0.0001] were the only significant associates of cough duration (Additional file 1: Table S6).
Multivariable models adjusted for age and illness severity.
Thus, the basis of more complex multivariable models is provided.
These associations remained significant in multivariable models.
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