The presented results from multivariable models incorporate formal imputation adjustments [ 16].
This did not hold in a multivariable model incorporating all significant factors.
A multivariable model incorporating all 13 conventional risk variables was calculated with Cox proportional hazards regression analysis.
In a multivariable model incorporating the variables described in the "Covariates" section of the Methods, the adjusted odds ratio was 1.21 (95% CI, 1.11 1.32).
The multivariable model incorporating just the three serological cancer biomarkers had considerable overlap between the two lower-risk groups, indicating that the discriminative performance was considerably poorer than the 5-serological-cancer-biomarker model that included bilirubin and albumin (Harrell's C of 0.69, AIC 2536).
A final multivariable logistic model incorporating dataset-specific information, i.e., breast cancer family history, was also explored for the LIDPBC data, and race/ethnicity was added to the final NHANES model.
We used a multivariable generalized linear regression using Poisson models incorporating externally standardized incidence rates (Breslow and Day 1987) to adjust the SIR for all the variables listed in Table 1.
However, in a Cox multivariable model that incorporated a post-treatment tumor profile (pathological T stage, N stage, Ki67 and ER status of the surgical specimen), the presence of tumor aromatase expression at baseline sample remained a favorable independent prognostic biomarker for both RFS (P = 0.01, HR 2.3, 95% CI 1.2 4.6 for absent expression) and BCSS (P = 0.008, HR 3.76, 95% CI 1.4 10.0).
When incorporated into multivariable models, sEng and IL18BP improved the diagnostic accuracy of clinical information alone.
To test whether matching of cases and controls in Shetland pony mares and Icelandic horses was successful, the relation between IBH (case or control, binary phenotype) and matching factors was assessed in univariable and multivariable models using the LOGISTIC procedure incorporated in SAS 9.2© software (SAS Institute Inc., Cary, NC).
