Within the confirmatory analyses, all variables within the multivariable models remained significant except a previous diagnosis of glaucoma.
When we removed the patients with imputed heights, the results of the final multivariable regression model remained consistent with the primary analysis in which those with imputed heights were included.
Of the 269 patients in the multivariable model, 80 remained on methotrexate monotherapy, while the others were randomised to add infliximab (n=94) or to triple therapy (n=95).
In multivariable models, ST2 remained independently associated with outcomes after adjustment for clinical variables and amino-terminal pro-B-type natriuretic peptide.
In multivariable models, gender remained significant (AOR 2.2 95%CI [1.56-3.18]).
Upon adjusting for confounders using multivariable models, NLR remained significantly associated with increased risk of recurrence (HR=1.49, 95% CI=1.12 2, P=0.007, Table 2), cancer-specific mortality (HR=1.88, 95% CI=1.39 2.54, P<0.001, Table 3) and overall mortality (average HR=1.67, 95% CI=1.17 2.39, P=0.005, Table 4).
Paternal smoking during childhood was associated with lower z-score of height-for-age only at preschool age, but when included at multivariable models not remained associated (p = 0.68) and did not affect the coefficient of association between maternal smoking and growth.
In a multivariable model, only dBP remained a significant predictor.
In the final multivariable model, 4 factors remained significant.
