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This did not hold in a multivariable model incorporating all significant factors.
A multivariable model incorporating all 13 conventional risk variables was calculated with Cox proportional hazards regression analysis.
In a multivariable model incorporating the variables described in the "Covariates" section of the Methods, the adjusted odds ratio was 1.21 (95% CI, 1.11 1.32).
The multivariable model incorporating just the three serological cancer biomarkers had considerable overlap between the two lower-risk groups, indicating that the discriminative performance was considerably poorer than the 5-serological-cancer-biomarker model that included bilirubin and albumin (Harrell's C of 0.69, AIC 2536).
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From the multivariable models incorporating omega-3 fatty acids (Model B), the adjusted OR for ANA positivity comparing females in the highest versus lowest tertile of hair mercury was 4.10 (95% CI: 1.66, 10.13), and for the highest versus lowest quartile of blood mercury was 2.32 (95% CI: 1.07, 5.03).
The presented results from multivariable models incorporate formal imputation adjustments [ 16].
A final multivariable logistic model incorporating dataset-specific information, i.e., breast cancer family history, was also explored for the LIDPBC data, and race/ethnicity was added to the final NHANES model.
When BMI and WC were analyzed separately for predicting risk of a first cardiovascular event, the c statistics associated with the multivariable CVD models incorporating BMI vs. WC were nearly identical in men and women.
However, in a Cox multivariable model that incorporated a post-treatment tumor profile (pathological T stage, N stage, Ki67 and ER status of the surgical specimen), the presence of tumor aromatase expression at baseline sample remained a favorable independent prognostic biomarker for both RFS (P = 0.01, HR 2.3, 95% CI 1.2 4.6 for absent expression) and BCSS (P = 0.008, HR 3.76, 95% CI 1.4 10.0).
We used a multivariable generalized linear regression using Poisson models incorporating externally standardized incidence rates (Breslow and Day 1987) to adjust the SIR for all the variables listed in Table 1.
Factors that were significant in the univariable model (p < 0.1) were then incorporated in the multivariable model.
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