In a supplementary analysis, we repeated the multivariable model additionally adjusting for A1C.
The second multivariable model additionally included systolic and diastolic blood pressure, antihypertensive drugs, total serum cholesterol concentration, educational level, and socioeconomic group.
We then present a full multivariable model additionally adjusted for the following putative confounding factors: BMI, smoking status, race, education, history of diabetes, physical activity, and other food groups.
Multivariable models additionally adjusted for the type of surgery (TSA versus HHR).
For comparability with other studies and our earlier published results of data from this study, we present results from parsimonious models adjusted for age alone, and from multivariable models additionally adjusted for potential confounders of race, education, smoking, history of diabetes, BMI, caloric intake, and physical activity.
Men in the SPORTSMART sample were more likely to report not using condoms for vaginal or anal sex on at least one occasion in the past year than men in Natsal-3 (81.4 % vs. 70.0 %), although not in the multivariable model after additionally adjusting for partner numbers (AOR: 1.57, 95 % CI: 0.93 2.64).
In a third supplementary analysis, we examined the independent association between IGFBP-3 and diabetes after adjusting for variables in the multivariable model and, additionally, IGF-1 levels.
The second multivariable model was additionally adjusted for exact age at prostate check clinic and family history, as these are the established risk factors for prostate cancer.
In the first model we adjusted for age (years) and sex and in the multivariable model we additionally adjusted for categories of education, cigarette smoking, alcohol consumption, diabetes mellitus, and BMI (kg/m).
The final multivariable model was additionally adjusted for other established risk factors and other potential confounders relevant to each subtype of esophageal cancer: education, BMI last year, smoking (pack-years), lifetime mean alcohol consumption, physical activity, NSAIDs, acid reflux symptoms in last 10 years (not for ESCC), presence of diabetes (not for ESCC), and selected dietary factors.
Addition of CRP, IL-6, C-peptide, and non-HMW adiponectin to the multivariable model that additionally included AFP significantly increased the AUC for the prediction of HCC from 0.777 to 0.855; GLDH increased the AUC from 0.803 to 0.836 (Fig. 3).
