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The variables with a univariable P-value ≤ 0.20 from the likelihood ratio test (LRT) and the multiple Wald test were selected for further multivariable analysis, provided that there was no colinearity between them.
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The positive association found between receipt of health promotion input and total SSAP scores in multivariable analysis provides evidence of the positive impact of health promotion efforts in helping to establish the programme.
The few studies that have undertaken multivariable regression analysis provide unreliable estimates because they did not include all the known independent clinical variables or the analysis had too few events for the number of variables assessed.
In multivariable analysis, SAF provided the highest HR of 4.9 (95% CI 2.4 9.9, P < 0.0001 [ Table 2]).
These variables were then incorporated in the multivariable analysis which provided one model that best fulfilled the selection criteria.
A combined face-to-face and remote lifestyle counseling rate analysis was also conducted; results for this multivariable analysis are provided in Supplementary Appendix A. In this large, retrospective study, we have demonstrated a strong association between lifestyle counseling and glucose, blood pressure, and LDL cholesterol control in patients with diabetes.
Although a prospective, controlled randomized clinical trial is, of course, the optimal means of demonstrating cause and effect, epidemiological studies with adequate multivariable analysis can provide valuable information.
Further evaluation of these factors utilizing a larger sample and appropriate multivariable analysis may provide further insight regarding the potential impact of specific determinants.
Although our results should be considered with caution in the absence of randomisation, the adjustment in the multivariable analysis should provide a reliable estimate of the effect of RT.
We refer to such an analysis as "multivariable Mendelian randomization".
Analysis provided by AAAS.
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