The predictive value of parameters was assessed by logistic regression analyses; parameters were selected for multivariable analyses when p was < 0.20.
Tumour grade was also added in the multivariable analyses when evaluating the independent effect of Ki-67 LI, molecular subtype and treatment.
This was mostly due to a retrospective study design, a small sample size, a poor definition of the study domain, an uncertain diagnosis of the determinant (that is, the occurrence of AF), and a lack of multivariable analyses when assessing risk factors.
The main limitation of this study is the small sample size which, although more than adequate for examining crude relationships among DMR methylation fractions, protein IGF2 concentrations and birth weight, may have been inadequate for multivariable analyses, especially when testing interaction by race and maternal BMI.
Third, although the quality of reporting of multivariable analyses appeared adequate when assessed using the guidelines proposed by Hayden and colleagues [ 32], when assessed in more detail using those suggested by Moss et al. [ 33] several methodological limitations became apparent.
While the quality of reporting of multivariable analyses appeared adequate when assessed using the guidelines proposed by Hayden and colleagues [ 32] (Table 2), when assessed in more detail using those suggested by Moss et al. [ 33] several methodological limitations became apparent (Additional file 1: Table S4).
The present study found an association between migraine and EDS in bivariate analysis, which was weaker in the multivariable analyses and disappeared when adjusting for all potential confounders, a finding similar to that of The Korean population-based study when adjusting for anxiety, depression, sleep duration and Pittsburgh Sleep Quality index score [22].
The results from the multivariable analyses were not meaningfully changed when we performed sensitivity analyses in which we excluded women with in situ breast cancer or when we reran analyses censoring women who developed a recurrence or new primary breast cancer at the time of these events.
IPFP area was not significantly associated with total knee pain and pain subscales in univariable analyses; however, IPFP area was significantly and negatively associated with pain when walking on a flat surface and going up/down stairs in multivariable analyses, and remained significant for pain when walking on a flat surface after further adjustment for radiographic OA (P <0.05, Table 5).
When adjusted in multivariable analyses (table 5) there was no statistically significant difference in error rates between admission and discharge.
In multivariable analyses, infants were at greatest risk for CLD when they had exposure to both chorioamnionitis and either mechanical ventilation >7 days (odds ratio, 3.2; 95% confidence interval, 0.9-11) or postnatal infection (odds ratio, 2.9; 95% confidence interval, 1.1-7.4).
