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In the multivariable analyses there was statistical evidence for interaction of age-group with systolic blood pressure (p for interaction <0.0001), LVH/strain (p for interaction = 0.02), and high sessional alcohol intake (p = 0.02), because effects of these variables appeared weaker in those with older age on the multiplicative scale that is underlying a Cox-model.
Despite the use of multivariable analyses, there were numerous potentially confounding variables that could not be adjusted for.
Our study was limited by the observational nature of the data and although we adjusted for confounding factors in our multivariable analyses, there is potential for unmeasured confounding.
Although heparin did not remain an independent risk factor for bleeding complications in any of the multivariable analyses, there was a trend towards heparin being a risk factor in all of the univariable analyses.
In multivariable analyses, there was statistical evidence for the association between RE and lymphedema, aOR 4.3 (95% CI 1.3-14.0), venous insufficiency aOR 2.3 (95% CI 1.0-5.2), skin disease aOR 1.9 (95% CI 1.0-3.7) and COPD, OR 0.2 (95% CI 0.04-1.0).
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Cerebrovascular disease was excluded from the multivariable analyses because there were considerable differences in the way it was defined in each registry.
Furthermore, 9 % of the women had missing values for physical activity levels and therefore this variable was not included in the multivariable analyses as there was no difference in physical activity levels according to smoking status.
In the multivariable regression analyses there was no strong or consistent statistical evidence for differences in associations between daughters and sons (all p-values > = 0.1 with few exceptions).
When adjusted in multivariable analyses (table 5) there was no statistically significant difference in error rates between admission and discharge.
In multivariable analyses restricted to men, there was a higher mortality rate in the cemented group and the uncemented group compared with the Birmingham hip resurfacing group.
In multivariable analyses of associations with IBS, there was a trend toward an association with higher values of IgG antibodies against Candida albicans (Table 2).
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