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In multivariable analyses including International Prognostic Index and interim positron emission tomography/computed tomography scans across both cohorts, molecular response was independently prognostic of outcomes, including event-free and overall survival.
Multivariable analyses, including computation of least squares (LS) means and standard errors (SEs) were done using general linear models [34].
Multivariable analyses including sociodemographic variables and aggravation by movement (Model 1) indicated that aggravation by movement leads to an increased OR for RLS ORR = 2.3, 95% CI = 1.1 4.8).
RESULTS: Multivariable analyses including preoperative hematocrit and other perioperative variables revealed that lowest hematocrit during CPB demonstrated a significant interaction with body weight and was highly associated with peak fractional change in serum creatinine (parameter estimate [PE] = 4.5; p = 0.008) and also with highest postoperative creatinine value (PE = 0.06; p = 0.004).
Data will be analyzed using univariate and multivariable analyses (including mixed effects regression analysis).
Cox proportional hazard regression was used in univariable analyses to obtain hazard ratios (HR), and for multivariable analyses including interaction testing.
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All multivariable analyses included a dummy variable for study (VTS vs. Ditrame Plus) to account for differing baseline risks between the two cohorts.
Note that our multivariable analyses included at mostsix predictors.
Multivariable analyses included variables (age and sex) determined a priori.
Multivariable analyses included linear regression using two different models.
Multivariable analyses included genetic variables with P values ≤ 0.15 using backward step multiple logistic regression.
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