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While multivariable adjustment and propensity matching mitigate the effect of measured confounders on the DES vs. BMS effect estimate, these approaches have limited ability to address the influence of unmeasured confounders.
This result was only significant after multivariable adjustment, and we are unaware of a convincing biologic explanation.
The inverse associations were attenuated after multivariable adjustment, and BMI was a primary confounder in the multivariable model.
The findings remained after comprehensive multivariable adjustment and strongly suggest a synergistic interaction between oral infection and inflammatory response.
Following multivariable adjustment and taking into account regression dilution, the risk was 17% higher (1.17 [1.06–1.28], P = 0.001).
No differences were detected between the two RCT intervention arms in occurrence of severe anaemia following multivariable adjustment and tests suggested equivalency.
Similar(48)
These associations remained robust after multivariable adjustments and were also maintained in sensitivity analyses adjusted for delays in initiation of resuscitation.
These associations remained significant even after multivariable adjustments and sensitivity analyses.
The exclusion criteria were (1) missing neutrophil and lymphocyte data at ICU admission, (2) missing covariate data for multivariable adjustments and (3) repeat admissions to the ICU.
The quality of these observational studies was moderate to low with fair level of multivariable adjustments and adequate exposure and outcome ascertainment.
This stepwise increase in risk of death remained statistically significant after multivariable adjustments, and similar trends in mortality were present for all secondary outcomes tested.
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