If there is one thing parents everywhere understand, it's the multitude of trial-and-error methods one will use to try and soothe a crying baby.
Dr. Goodman said their results might help explain a troubling phenomenon in medicine: All too often, despite a multitude of clinical trials on a particular subject, the data do not supply the answers doctors need to treat patients.
Several major anti-angiogenic drugs are already in the clinic, and a multitude of clinical trials for various cancers are in progress [1].
If we take into account the preceding multitude of unfavorable trials and analyze these results in the light of a mild-moderate skeptical view, the current probabilities for these two trials rise to 0.14 and 0.21, respectively.
This is in contrast to adherence interventions, for which a multitude of randomised trials have been done or are underway and focus on adherence in patients who remain in care, often predominantly soon after initiating ART [25].
Based on the multitude of clinical trials already published [1], the recent FDA approval of a new therapy on sepsis [3], and a 28-day mortality ranging from 30 40%, no new therapy for severe sepsis will likely be accepted by clinicians or regulators if the relative risk reduction (RRR) for mortality is not greater than 15 25% (absolute risk reduction (ARR) ≥5 10%).
The efficacy of systemic antibacterial prophylaxis was investigated in a multitude of clinical trials and several meta-analyses.
A multitude of clinical trials conducted so far has not achieved significant benefit for patients with MM.
A multitude of clinical trials are assessing the safety and efficacy of novel treatments in patients with refractory HER2+ MBC (Table 1).
The largest cumulative study sample sizes on a national level could be attributed to the multitude of clinical trials conducted in Sweden, the United Kingdom, and Norway.
Considering the multitude of clinical trials and the multitude of treatments such methods are urgently needed and with certain study designs and endpoints this may be an appropriate procedure.
