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NPAS3 was found in the current study to be associated with a multitude of phenotypes including two inflammatory markers IL-1β and IL-6.
Because mutations in LAMA2 cause a multitude of phenotypes that are based on LM-211 affecting multiple pathways, we now examined whether a combined treatment exerts additional benefits and could increase treatment efficacy.
In C. elegans, the multitude of phenotypes produced by the reduction in IIS are all suppressed in the absence of the worm FOXO transcription factor, DAF-16, suggesting that they are all under common regulation.
We used multiple wild C. elegans populations freshly isolated from local sites to investigate gene sequence polymorphisms and a multitude of phenotypes including the transcriptome, fitness, and behavioral traits.
The large body of literature produced over the years has reported that ATM variants can have different and frequently opposing effects in cancer predisposition, which causes a multitude of phenotypes.
However, the multitude of phenotypes observed in the DME cells of foscrb Y10A mutant embryos, such as persistence of CrbY10A, DPatj and Baz proteins and decrease of Ed expression at the LE, as well as disruption of the supracellular actomyosin cable and disorganised filopodia, suggest that Crb performs also specific functions in the DME.
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Then, as they age, they acquire diverse tissue-specific functions outside of the testis, possibly facilitating the evolution of a multitude of complex phenotypes across species.
Thus, duplicate genes acquire a diversity of new tissue-specific functions outside of the testis, possibly contributing to the origin of a multitude of complex phenotypes during mammalian evolution.
Like in the mouse, our findings suggest also for humans a patchwork of different Pcnt splice variants in different tissues, which may explain why mutations in the human PCNT gene generate a multitude of different phenotypes.
Symbiotic microorganisms have been found in almost all arthropod lineages, where they can induce a multitude of different phenotypes, including, for example, defense against pathogens and changing of host sex ratios and behavior (Buchner 1965; Moran et al. 2008).
The multitude of pathological phenotypes that can arise in patients carrying the A3243G mutation stems from the fact that the mutation has a generic effect on the process of translation and protein production of mitochondrial components [8].
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