Sentence examples for multitude of mutations from inspiring English sources

The past several years have witnessed the discovery of a multitude of mutations underlying the development of human heart disease.

A multitude of mutations scattered throughout the 5592 bp coding sequence have been described.

A multitude of mutations have been described and are found to be scattered throughout these two large genes.

DOI: http://dx.doi.org/10.7554/eLife.00380.002 Clinically detectable cancer cells carry a multitude of mutations and chromosomal aberrations, and they display an enormous genetic heterogeneity (Salk et al., 2010; Wong et al., 2011; Brosnan and Iacobuzio-Donahue, 2012; Marusyk et al., 2012; Turner and Reis-Filho, 2012).

It is obvious that USCE does not reflect the multitude of mutation mechanisms observed in cancer cells with chromosomal instability.

Despite the multitude of genetic mutations being associated with the RP phenotype, the clinical and functional manifestations of the disease remain the same: nyctalopia, visual field constriction (tunnel vision), photopsias and pigment proliferation.

This genetic strategy led to the efficient isolation of a multitude of mouse mutations.

Clearly, the next major challenge will be to determine the pathogenicity of a multitude of potential mutations.

There are a multitude of pathogenic mutations reported in human mtDNA that associate with divergent clinical phenotypes [8], with a typical example being the A3243G mutation in the gene encoding mitochondrial tRNALeu [154].

Considering the trillions of cells in the human body, the multitude of possible mutations that can or do occur and the ensuing genomic instability, we can conclude that our ability to restrain the aberrant growth and behavior of precancerous cells is extremely efficient (Bissell and Hines 2011).

The emergence of transmissible drug-resistant Mycobacterium tuberculosis is the result of a multitude of additional genetic mutations, many of which interact, a phenomenon known as epistasis.