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There are now a multitude of implementations based on this concept that introduce additional functional data such as protein interaction data [ 55, 56], gene regulatory networks [ 57], pathway topology information [ 58], metabolic changes [ 59, 60] or expression kinetics [ 61].
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The relational model offers a simple expressive language (usually SQL) with a multitude of efficient implementations.
Unless clinical benefits are compelling, widespread clinical application of pharmacodynamics-based dosing (PDD) is unlikely, given the multitude of barriers to their implementation.
As QMS implementation is interwoven with a multitude of organisational, process and technological changes/innovations, we resort to methodological tools used in the case of innovation adoption.
Our study has shown that the participation of GPs in an IHSN is a complex phenomenon that depends upon a multitude of professional and organizational factors throughout the program implementation process.
Uploading data and running calculations via the OpenTox API and its implementation by AMBIT services generates a multitude of linked resources, all available via their RDF representations.
Evidently, the process of policy making and policy implementation is an entangled process in which a multitude of actors and factors play their part (Wincott 2010; Rigby et al. 2007).
The implementation of ECCI was a considerable challenge due to a multitude of factors, including: the wide variability of local IT infrastructures across health-boards, variations in the technologies used, available personal and resources, training, organisational and stakeholders' support and variations in the perceived benefits of the implementations[ 46, 47].
Hence, SMMs may facilitate the implementation of complex system-level change involving the inputs of a multitude of diverse actors.
Despite the multitude of preceding and adjacent stages offered in literature, studies analyzing turnaround success focus on measurable implementation phases that can be summarized under the aforementioned two stages.
Second, context specificity of a multitude of professional work-roles and circumstances would appear to require a multitude of different validated tools, thus making implementation problematic and potentially unworkable [ 4].
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