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Lung cancer is a complex disease caused by a multitude of genetic and environmental factors.
Despite the multitude of genetic mutations being associated with the RP phenotype, the clinical and functional manifestations of the disease remain the same: nyctalopia, visual field constriction (tunnel vision), photopsias and pigment proliferation.
The 10-year project is probably the first ever to collect data on a multitude of genetic and environmental factors in autism in real time.
The pathologies of numerous retinal degenerative diseases can be attributed to a multitude of genetic factors, and individualized treatment options for afflicted patients are limited and cost-inefficient.
Although tumors develop in mice, the fundamental steps in tumorigenesis have already occurred and tumors display a multitude of genetic abnormalities.
It is becoming increasingly clear that a multitude of genetic and environmental factors interact at different points during the course of an individual's life to determine disease susceptibility[2].
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Given the challenges faced in interpreting the clinical significance of multitudes of genetic variants found in for example, whole genome sequencing [ 25], accruing evidence across multiple studies will advocate loci outside of known genes or other regulatory elements for further study, particularly for rare variants.
Thus, increased risk for development of tendon pathology with increased BMI or waist girth indicates that the variables (tendon pathology and BMI) are associated, despite the multitude of other genetic and non-genetic risk factors.
The emergence of transmissible drug-resistant Mycobacterium tuberculosis is the result of a multitude of additional genetic mutations, many of which interact, a phenomenon known as epistasis.
Application of Bayesian linear mixed models, in which each trait was evaluated against multi-SNP models, identified a multitude of new genetic associations (see Table S3).
It is certain that altered gene expression can not only be attributed to disruption of regulatory/signaling cascades and downstream effects, but also to a multitude of causal genetic and epigenetic aberrations.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com