As the trials whose results were analyzed involved the use a multitude of agents, some of them with limited activity in advanced disease, the subgroups are shown and described individually.
A multitude of agents inhibiting EGFR are in various stages of development and encouraging single agent activity has been reported in recurrent or metastatic HNSCC (Cohen EE et al, 2003; Soulieres et al, 2004).
Unfortunately, most patients still experience relapse, and a multitude of novel agents are currently being tested in this setting, including proteasome inhibitors with bortezomib (the first of its class and first Food and Drug Administration approved drug in MCL), mammalian target of rapamycin inhibitors, Bcl-2 inhibitors, and antiangiogenesis agents, among others.
A multitude of different agents can induce autophagy, but their ability to induce mitophagy is debated.
There are a multitude of chemosensitization agents used in cancer therapy, many of which are appealing to use in HIV.
Topical therapy of OPC can be accomplished with a multitude of antifungal agents including nystatin, amphotericin B, clotrimazole, and, more recently, miconazole (Table 1).
The adaptation processes after each transition were strongly influenced by an iteration between responses by a multitude of individual agents and government efforts to revise the rules of the game, through a series of policy initiatives.
Do infections play a pathogenic role by evoking immune reactions, for example resulting from molecular mimicry with a specific microbe or from repeated exposures to a multitude of foreign agents triggering a wear and tear type of immune defence?
Recent studies have utilized this model organism to identify whole genome mutational profiles of a multitude of genotoxic agents (Flibotte et al. 2010; Sarin et al. 2010; Meier et al. 2014).
For endoparasites the host with its different spatial niches, nutrient resources and specific immune system directed against the parasite, is a far better defined habitat than a marine rocky shore or a natural forest with their multitude of interacting agents [ 7].
While pharmacokinetic data concerning a multitude of antimicrobial agents used to treat peritonitis for patients maintained on CAPD has been well defined, there is a little scientific data to support the ISPD recommendations for treating patients with CCPD [ 24, 38, 39].
