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An alternative explanation could be that the data from analysing TB40-E and AD169 suggests that KAP1 binding to the viral genome is irrelevant and that any KAP1 effects observed in Figure 1 are indirect due to the multitude effects KAP1 KO would have on other cellular function which then impact on HCMV gene expression.
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Further studies are urgently required in order to better understand this multitude of effects (in particular the effects on miRNA and cellular acetylome).
A specific feature of this kind of regulation is its promiscuity (the ability of one microRNA to interact with numerous targets) and, as a consequence, a multitude of effects (Carthew and Sontheimer 2009; Esquela-Kerscher and Slack 2006; Ma and Weinberg 2008).
It is unlikely that the effect of climate change on a specific pathogen will be idiosyncratic; rather, a multitude of effects are likely to occur because pathogen dispersion, transport, fate, and environmental exposure pathways can all be altered by local climate and weather conditions (Boxall et al. 2009).
There would be, environmentalists complain, a multitude of effects.
However, low temperatures have a multitude of effects, not all of which are desirable or beneficial.
However, low temperatures have a multitude of effects, not all of which are beneficial.
The author is unaware of any previous attempts to develop plate theory formulations capable of considering the multitude of effects incorporated into the proposed framework.
Despite the fact that vampire bat venom has a multitude of effects unaccounted by the documented bioactivities of DSPA and draculin, efforts have not been made to establish what other bioactive proteins are secreted by their submaxillary gland.
Tumor necrosis factor-alpha (TNF-α), a polypeptide cytokine produced primarily by mononuclear phagocytes, plays a key role in the initiation of the inflammatory response but has a multitude of effects in many tissues.
Neuroscience has shown us that stress has a multitude of effects on cognition and memory.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com