Sentence examples for multistep pathogenesis of from inspiring English sources

(2009) describe the elegant use of this approach to dissect, but not completely replicate, the multistep pathogenesis of TEL-AML1+ leukemia.

In one study, it was found that the expression of OATPs and enhancement ratio of HCCs in the hepatocellular phase decreased with poorer tumour differentiation, which reflected the known multistep pathogenesis of these tumours.

These findings indicate that the reduction in arthritis severity in NMU-KO mice was due neither to impaired differentiation nor a decreased inherent functional capacity of the main innate immune cell types that contribute to the multistep pathogenesis of arthritis in this model.

Although the oncogenicity of lung cancer-related genes has been studied extensively, there is limited knowledge of the process of malignant transformation and the regulatory mechanisms of multistep pathogenesis, especially the regulatory network of lung cancer-related genes, which urgently need to be studied [ 5].

Studies have described the role of EMMPRIN in the stimulation of several metalloproteinases and proangionenic factors from tumor and adjacent stroma cells that could contribute to tumor multistep pathogenesis [ 27].

Oncogenomic studies have identified many potential therapeutic targets and have led to emerging models of the multistep molecular pathogenesis of MM.

Epigenetic inactivation of multiple tumour-suppressor genes (TSGs) is a key molecular event in the multistep genetic pathogenesis of cancer.

Although many markers have been studied and have given new understanding of cancer pathogenesis and progression as a potential contributor to multistep process of oncogenesis they are not yet ready to be used as prognostic significance in routine clinical investigative and therapeutic procedures in patients with these tumors.

The pathogenesis of RA is a multistep process that starts with the development of autoimmunity, continues with local inflammation and finally induces bone destruction.

Similar to RA, the pathogenesis of CIA is a multistep process driven by major histocompatibility complex restricted T cells that mediate destruction of the joint characterized by fibrin deposition, synovial inflammation, periosteal bone formation, pannus formation and ankylosis of one or more articular joints [ 6, 8].

The pathogenesis of oral cancer is a multistep process which involves sequential progression of normal mucosa through a continuous spectrum of lesions, including hyperplasia, dysplasia, carcinoma in situ, and invasive carcinoma [ 14, 15].