Sentence examples for multistep development of from inspiring English sources
This data is consistent with the "Hallmarks of Cancer" concept proposed by Weinberg et al. [9] where certain biological capabilities are acquired during the multistep development of human tumors [10, 11].
(1, 2) The multistep development of HCC is characterized by the progressive sequential evolution associated with chronic liver damage.
Ten biological capabilities acquired during the multistep development of human neoplasms form the hallmarks of cancer [[ 38]].
Recently, it was reported that sequential molecular abnormalities were involved in the multistep development of squamous cell carcinoma of the lung (Wistuba et al, 1999, 2000).
The multistep development of AP involves a complex cascade of local and systemic events that occur in response to stress by the acinar cells, but the underlying cellular and molecular mechanisms are not well understood.
In the veterinary mycoplasmas, mutations in position A2058 have been associated with increased MIC levels, but only in a background of other mutations in the 23S rRNA gene, suggesting multistep development of significant resistance [ 82].
The multistep development model of breast cancer involves the progression from premalignant hyperplastic lesions, to pre-invasive carcinoma (ductal carcinoma in situ (DCIS)), to invasive ductal carcinoma (IDC).
In addition, renal tumorigenesis in VHL disease appears to be a multistep process, as development of VHL-deficient renal cysts precedes onset of renal cancers [ 4].
As for most epithelial cancers, the incidence of human breast cancer is age dependent, implicating a stochastic multistep progression in the development of this disease [ 4].
Colon cancer involves the development of a multistep stage in which micro-adenomas and aberrant crypt foci (ACF) are the morphological markers [14].
Proteomic studies are widely used in the search for new tumour markers Carcinogenesis is a multistep process leading to the development of multiple cell clones and heterogeneity as a result of tumour cell genetic instability.
