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Under the multistage theory of carcinogenesis, this pattern of risk indicates an early stage effect.
The classical way of quantitatively evaluating incidence data comes from the multistage theory of carcinogenesis [ 3].
It is argued that these results support the multistage theory of carcinogenesis.
Implications of the multistage theory of carcinogenesis for evaluating the effect of exposure to carcinogens in the workplace are described.
In the cancer paradigm, the multistage theory of carcinogenesis has provided the basis for developing corresponding statistical models.
I interpret these patterns in light of a multistage theory of aging, developed by analogy with multistage models of cancer progression [ 8- 11].
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Multistage theories of carcinogenesis predict that a person's susceptibility to benzene-induced leukemia will depend upon the age at which exposure occurs, as the probability of transition through the stage (or stages) of the disease process unaffected by benzene exposure are assumed to be age dependent (Thomas 1988).
Multistage theory for the kinetics of carcinogenesis makes three qualitative predictions.
Later on, other types of experimental evidence, based on epidemiological data of cancer mortality, allowed the development of the multistage theory (MST) of cancer development [ 15- 18].
He concludes that, "until we have clear evidence for more than two stages, it seems best to regard the multistage theory, like the dogmas of certain religions, as permitting either a literal or figurative interpretation".
The midlife rise in acceleration may also be explained by a multistage theory if the rates of progression between stages rise slowly during midlife [ 12]. Figure 1 illustrates mortality patterns for non-Hispanic white females in the United States for the years 1999 and 2000.
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