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A multistage sequence of histopathological and molecular changes has been identified for gallbladder carcinoma, which is especially well-defined for tumorigenesis associated with gallstones.
Thus, the multistage sequence of events has many phases for prevention and intervention.
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Derived from a larger RNA precursor (pri-miRNA), the miRNA transcript is processed in a multistage sequence, culminating in the cleavage of a short hairpin RNA to form a mature ∼22 nucleotide miRNA [4].
Lignin removal of up to 50% from E. globulus wood was attained using this laccase-mediator pretreatment (with 50 U · g-1 of laccase and 3% of methyl syringate) followed by an alkaline peroxide extraction in a multistage sequence.
Considerable past work has emphasized the potential for age-related differences in long-term risks from carcinogenic exposures that could result from early- versus late-life exposure to carcinogens that tend to cause mutations at a single stage that is either early or late in the multistage molecular pathologic sequence of genetic changes (Brown and Hoel 1986; Day and Brown 1980; Whittemore 1977).
In sum, despite these caveats in interpretation, the temporal precision of the aMEG approach employed in our study offers insight into the functional anatomy and the temporal sequence of the multistage joke comprehension process as it unfolds in time.
We suggest that the evolving dynamic topography field has played a key role in facilitating development of placer deposits, largely through multistage, eastward reworking of near-shore sequences during highstand transgressive cycles on a progressively tilting platform under the influence of persistent westerly weather systems.
In 1988, Vogelstein et al. proposed a multistage theory of carcinogenesis known as the adenoma carcinoma sequence, in which colorectal cancer (CRC) arises because of mutations that activate multiple oncogenes and inactivate tumor-suppressor genes.
In conclusion, our results revealed the multistage heterogeneity of tissue-infiltrating TCR repertoire during carcinogenesis.
Combusting coal electro conductivity has complicated multistage type of change.
Similarly, NO appears to exert a dichotomy of effects within the multistage model of cancer.
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