In conclusion, results of this study demonstrate that sporadic CRC multiplicity is associated with gene promoter methylation.
In a pilot study in vivo, we observed that dietary MSC, but not SM, inhibited mouse colon tumor multiplicity, and this was associated with increased Bmf expression and histone acetylation in the tumors, without marked changes in overall HDAC8 protein levels (Supplementary Figure 5).
After multiplicity correction, only working memory was associated with work/education outcome.
In intact rats, in which both hormonally responsive and hormonally nonresponsive carcinomas arise, celecoxib treatment was associated with reductions of tumor multiplicity of 56%and74%4%.
The risk of advanced neoplasia within subcentimetric lesions was associated with increasing age, male sex, polyp morphology, polyp multiplicity, and occult or overt blood in the stools.
In contrast, mutations in genes with lower gene maximum multiplicity values may be associated with the environment (anatomic location) and the specific cell type in which they occur.
However, in multivariate analysis, only the age, the size of the largest recurrent tumors, and multiplicity of recurrence were associated with the optimal cytoreduction.
In univariate analysis, the age at recurrence, the size of the largest recurrent tumors, the site of recurrence (retroperitoneal or not), and multiplicity of recurrence were associated with optimal cytoreduction (R0 and R1) (P = 0.013, 0.022, 0.086, and 0.03, respectively).
Multivariate analysis showed that the age at recurrence, the size of the largest recurrent tumors, and multiplicity of recurrence were associated with the optimal cytoreduction (P = 0.046, 0.028, and 0.044, respectively) (Table 3).
In univariate analysis, the age, PFI, the size of the largest recurrent tumors, the site of recurrence, and multiplicity of recurrence were associated with optimal cytoreduction, which indicates that patients with younger age, longer PFI, smaller tumor size, and recurrent site not in retroperitoneal, and single recurrence are more likely to achieve optimal cytoreduction.
