To address issues of multiplicity relating to multiple-dose comparisons and multiple variables of interest, a fixed-sequence testing procedure was adopted.
Improvement in the imaging capabilities of CTP does allow for a non-invasive assessment of the cerebral circulation dynamics, but it is liable to the inter-evaluator variability and lack of clear interpretation paradigms given the multiplicity of variables involved in generating and influencing these images [9, 10].
In addition, due to the composite nature of reinforced masonry construction, the evaluation of multivariate fragility functions may likely require significant computational effort, owing to the multiplicity of variables describing the constituent materials and their associated uncertainty.
The aim is to make this method effectively usable in actual compost production conditions involving large amounts of organic materials to be treated, a multiplicity of variables to be taken into account, very narrow profit margins, and the need to take certain decisions quickly.
Indeed, overall survival may be dependent on a multiplicity of variables, not necessarily on expression of drug transporters.
Potential limitations of our work include the relatively small sample size, along with the multiplicity of variables being considered.
However, these studies used expected costs based on estimates and did not take into account the multiplicity of variables that determine costs.
Case study has been described as a 'study of the particular' (p XI) [ 2] as it is allows for the study of highly context-bound phenomena with a multiplicity of variables not amenable to control.
It also shows the potential of PLS modelling to screen and rank a multiplicity of variables for associations with caries in small clinical samples (n = 30): revealing a wide but shallow gliding scale of 1/5th influential caries protecting or promoting and 4/5 non-influential variables.
However, the exploration of important parameters in combustion systems of practical application is difficult, due to the multiplicity of dependent variables.
