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Based on the hypergeometric distribution, we found that the enrichment in genes with promoters similar to histone genes is statistically significant (p-value of 2.12E-55, and corrected p-value for multiplicity testing of 7.13E-51; withypergeometricic parameters of N=33,596, n=141, K=1,207, k=65), thereby validating our hypothesis.
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After adjustment for multiplicity testing, none of these factors were associated with the distribution of the CNAs.
Additionally, because of the multiplicity of testing between pairs of regression lines, the chance of error increases so a more stringent significance level should be adopted.
First, it faces the problem of multiplicity from multiple testing.
However, such multiplicity of testing decreases the power of the Grubbs' test and this use of repeated significance tests in a single study can thus increase the probability of obtaining false positive results.
The minimum false discovery rate (FDR) at which each null hypothesis could be rejected using the method of Benjamini and Hochberg (1995) is also provided as a conservative statistical adjustment for the multiplicity of testing multiple gene models.
However, such a simplified approach would neglect the problem of multiplicity of testing and statistical variation associated with each measurement.
We set the type 1 error rate at a low level (alpha = 1%) to account for the multiplicity of testing, with a power of 95%.
It is not at all clear that such hierarchical RT-PCR protocols, attempting to increase analytical multiplicity through serial testing of the same specimen(s) at different laboratory venues over a period likely longer than a single day can be either efficient or cost-effective.
The use of full Bayesian statistics can account for problems of multiplicity due to multiple testing [ 24, 40, 41].
Correction for multiplicity of testing is planned by identification of correlations between the variables, i.e. those of autonomic tone.
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CEO of Professional Science Editing for Scientists @ prosciediting.com