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Overall, genes with high gene maximum multiplicity scores were significantly more likely to be causal genes than those with lower gene maximum multiplicity scores (two-sample Kolmogorov-Smirnov test, one-tail, D34, 455 = 0.632, p < 0.05).
The first study tests whether high multiplicity scores correlate with known causal genes; it also explores the use of multiplicity combined with hierarchical clustering to organize mutated genes.
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The median gene maximum multiplicity score for known causal genes was 5.5; for all other genes, it was 1.0.
Further uncertainty arises because of the multiplicity of scoring methods of the GHQ-12.
We obtained information on important covariates, including maternal age, parity, educational level, smoking during pregnancy, child sex, birth weight, gestational age, multiplicity, Apgar score, and death or emigration, from the Medical Birth Register 11 and Statistics Denmark.
In the first iteration of this assessment, we have used tumor multiplicity alone to score the phenotype.
After adjustment for test multiplicity, the global score was affected by Burning, Dimming of vision, Reading and Trouble seeing at night.
For skin tumor multiplicity, the peak LOD score of 3.93 (above the 95% LOD threshold of 3.17) was located near marker rs4138000 at 75.83 Mb; the 1.5-LOD support interval spanned from rs32779838 mapping at 41.15 Mb to rs13464873 at 130.15 Mb.
In contrast, using the AOM/Il10−/− model, we observed a strong correlation between inflammation score and tumor multiplicity.
All significant (P<0.05) gene categories were determined by EASE score, corrected for multiplicity with the global false-discovery rate function using 1000 iteration trials.
The peak LOD score for lung tumor multiplicity was 8.74, greater than the threshold for significant linkage (95% LOD threshold = 3.19).
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