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Though one reason for use of a composite is to reduce the multiplicity problems associated with multiple separate endpoints, composites can do so only if it is agreed that treatment impact on each of the endpoints is of value and if the endpoints move in the same direction.
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To safeguard against potential problems associated with multiplicity of analyses, 97 our solution is twofold.
Finally, while other guidelines advise to keep sub-group analyses to a minimum, because of the inherent problems associated with multiplicity of testing [ 3] we were more concerned with under-analysing data.
Problems associated with drilling.
He acknowledged problems associated with the development.
Understand the problems associated with hypertension.
Miller and Sim argue that most physicians "consider EMRs to be challenging to use because of the multiplicity of screens, options and navigational aids" [[ 19], p.120] The complexity and usability problem associated with EMRs results in physicians having to allocate time and effort if they are to master them.
In this study, by using the spectral theory of self-adjoint compact operators in Hilbert spaces, we prove that the spectrum of the spectral problem associated to (1.1) with 1 < α < 3 / 2 consists of only countable real eigenvalues with finite multiplicity and the orthogonal completeness of the corresponding eigenfunction system in the Hilbert spaces.
Multiplicity problems arise when the multiple individual components of a composite endpoint are intended as possible claims.
However, this last analysis was a subgroup analysis with multiplicity problems.
The inherent orientation of UML towards software, its unnecessary complexity [18] and its model multiplicity problems [19] cause intra- and inter-model consistency problems [20].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com