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When appropriate, we corrected for multiplicity of statistical tests using standard procedures [54], [55].
The multiplicity of statistical inferential tests was taken into account.
Multiplicity of statistical testing will be addressed in the detailed statistical analysis plan.
No adjustment for multiplicity of statistical analyses was performed in this exploratory study.
P-value under 0.0125 (=0.05/4) was considered significant to avoid type 1 errors in the multiplicity of statistical analysis.
Our further analysis of these parameters did show significance for the first two of these against near pCR, but there was no durable pattern to this finding and it could be owing to multiplicity of statistical analysis.
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Multiplicity of the statistical testing was indicated by multiple markers and multiple end points; the numbers of markers in each sample type are shown in table 2. Six baseline disease characteristics and one clinical response end point were used.
However, as a total of 65 different covariates were examined, Hochberg's adjustment was computed and p-values of approximately 0.001 or less met the multiplicity adjusted level of statistical significance [ 21].
However, such a simplified approach would neglect the problem of multiplicity of testing and statistical variation associated with each measurement.
Their disadvantages are: the multiplicity of arms; the complexity of statistical analysis; the lack of evaluation of the targeted molecule in the general population; the small number of patients included with a risk of ignoring rare adverse events; the absence of comparison with the therapeutic standard and finally, the lack of evaluation of the impact of treatment on overall survival.
As the detection of differentially expressed genes involves performing a large number of statistical tests, multiplicity needs to be taken into account when determining the significance of the detections.
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